Article | REF: J2160 V1

Polymorphism and solid phase transition in solution

Authors: Denis MANGIN, François PUEL, Stéphane VEESLER

Publication date: March 10, 2008

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2. Reminders on nucleation and growth in solution

A more detailed description of these concepts can be found in the literature ([1] [J 2 710] ). Only the main definitions are given here.

2.1 Sursaturation

If we consider a supersaturated solution, the driving force for crystallization is the difference in chemical potentials between the molecules in the supersaturated mother solution µ and those in the saturated solution µ s at crystal-solution equilibrium. This difference is written, per mole of molecule that will crystallize :

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Reminders on nucleation and growth in solution