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3. Polymorphism and solid phase transitions in solution
3.1 Solubility curves
As a first step, let's consider a system with two polymorphic varieties I and II, polymorph II being more stable than polymorph I. The more stable has the lower free enthalpy:
At equilibrium, polymorph i (i = I or II) is in contact with its saturated solution. The free enthalpies or chemical potentials are identical for each species in the solid and liquid phases, and becomes :
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Polymorphism and solid phase transitions in solution
Basic laboratory data for solid-phase development
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