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6. Outlook
Centrifugal partition chromatography has a technological maturity level (TRL) of 7 on a scale of 1 to 9, i.e. pilot-scale demonstration. The technologies developed are available at production scale (5 to 25 L columns, with flow rates of the order of 1 L · min –1 ) and the methodology for scaling up has been validated. The key engineering points have been covered in this article and are well understood. Processes currently under development are being scaled up to industrial scale (large-capacity preparative columns or production columns), for applications involving the purification of molecules, in the pharmaceutical and cosmetics industries, and in particular for biotechnologies (use of micro-organisms, yeast, bacteria, animal cells or microalgae, for the production of molecules of interest) for the valorization of metabolites.
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Conclusion
Bibliography
Events
CCC (CounterCurrent Chromatography) International Congress, held every two years
Patents
FR 2 920 674 (A1) – Cells and binding channels for centrifugal partition chromatography (2009)
FR 2 953 144 (A1) – Device and method for bringing immiscible fluid phases into contact by centrifugal force (2009)
FR 2 908 054 (A1) – CPC-type liquid-liquid separation process and system for eliminating cavitations (2008)
FR 2 923 398 (A1) – Centrifugal partition...
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Everseiko Corporation (Japan) http://www.everseiko.co.jp/scientific/hpcpc.html
Gilson – Armen Instruments (France) http://www.armen-instrument.com/
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