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Article | REF: CHV2210 V1

Usage of 1.3 dicarbonyl derivatives in domino and multicomponent reactions

Authors: Damien BONNE, Thierry CONSTANTIEUX, Yoann COQUEREL, Jean RODRIGUEZ

Publication date: May 10, 2010, Review date: October 17, 2017

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2. Enantioselective domino and multicomponent reactions

In recent years, the growing interest of pharmaceutical and agrochemical companies in the production of enantiopure molecules, i.e. in a single enantiomeric form, has led to an unprecedented demand for new enantioselective synthesis methods. The two enantiomers of a chiral molecule (a drug, for example) can have different physiological effects.

An infamous example is thalidomide (figure 31 ), a drug marketed in the 1950s whose right-hand form has sedative properties, while the left-hand form causes congenital malformations.

Similarly, the two enantiomers of limonene have different olfactory responses (figure 31 ).

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Enantioselective domino and multicomponent reactions
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