Article | REF: IN159 V1

Redox isomerization: an atom-economy reaction with a strong innovative potential

Authors:  Vincent Bizet, Dominique Cahard, Sylvain Gaillard, Jean-Luc Renaud

Publication date: August 10, 2013

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6. Outlook and developments

When it was first discovered in the early 1960s, redox isomerization was a laboratory curiosity, carried out under drastic conditions that were hardly compatible with functionalized substrates. Today, with the development of organometallic chemistry, it has become a reaction compatible with many substrates, and is used industrially for menthol synthesis. It is also associated with various processes via tandem, sequential reactions (aldolization, alkylation, fluorination, etc.). Other tandem reactions, such as tandem redox isomerization/reductive amination and tandem redox isomerization/C-H activation...

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