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ABSTRACT
Multicomponent reactions are currently in wide use, as they are perfectly in keeping with the development prospects of a more environment friendly chemistry. In this domain, the implementation of processes catalyzed by transition metals plays a major role in the elaboration of new methodologies, allowing for the combination of complexity-diversity-selectivity, which difficult to achieve with traditional methods. This article thus details the principle of multicomponent reactions and their interest in green chemistry, due notably to the reduction in the number of atoms and stages involved. It also presents the advantages of metal-catalyzed multicomponent reactions.
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Read the articleAUTHORS
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Geneviève BALME: CNRS Research Director - Institute of Molecular and Supramolecular Chemistry and Biochemistry (UMR5246), - Claude Bernard Lyon 1 University
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Nuno MONTEIRO: CNRS Research Fellow - Institute of Molecular and Supramolecular Chemistry and Biochemistry (UMR5246), - Claude Bernard Lyon 1 University
INTRODUCTION
Although the first multicomponent reactions were developed in the second half of the xix e century, it wasn't until the end of the xx e century that interest in these issues was revived. Indeed, it was at this time that environmental protection concerns gradually entered the chemistry sector. These new approaches, which provide access to complex molecules in a single operation, are particularly well-suited to meeting the challenges and issues of green chemistry, in particular time, energy and atom savings, waste and risk limitation, convergence and simplicity.
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Bibliography
Other works
ISAMBERT (N.) and LAVILLA (R.) – Heterocycles as key substrates in multicomponent reactions: the fast lane toward molecular complexity. Chem. Eur. J., 14, p. 8444-8454 (2008).
ULACZYK-LESANLO (A.) and HALL (D.G.) – New multicomponent reactions for generating libraries of polycyclic natural products. Curr. Opin. Chem. Biol. 9, pp. 266-276 (2005).
GANEM (B.) – Strategies for...
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