![](/assets/images/picto-drapeau-france-3a76576a5d60a512053b4612ab58dae5.png)
3. Passerini's reaction
3.1 General information and applications
The reaction involving a carboxylic acid, a carbonyl compound and an isonitrile to lead to the formation of an α-acyloxycarboxamide was discovered in 1921 by Mario Passerini (figure 12 ) [18] [19]. It is the first multicomponent reaction involving isonitriles [20].
The mechanism of this reaction has given rise to much discussion [21] and is still subject to controversy [22] [23] [24] [25] [26] [27]. One important observation is that the Passerini reaction is accelerated in low-polar aprotic solvents (CH 2 Cl 2 , Et 2...
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
![](/assets/images/logo-eti-286623ed91fa802ce039246e516e5852.png)
The Ultimate Scientific and Technical Reference
This article is included in
Green chemistry
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Passerini's reaction
Bibliography
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
![](/assets/images/logo-eti-286623ed91fa802ce039246e516e5852.png)
The Ultimate Scientific and Technical Reference