Français
2. Quality aspects of recombinant proteins
2.1 Post-translational changes
Posttranslational modifications (PTMs) include protein aggregation, methionine oxidation, deamination of asparagine and to a lesser extent glutamine, lipid addition, proteolysis, γ-carboxylation, glycosylation and protein sulfation .
Such modifications not only represent a challenge for the production process, but above all can have undesirable consequences for the patient. Incorrect TPMs can not only reduce the protein's efficacy, but...
The Ultimate Scientific and Technical Reference
This article is included in
Bioprocesses and bioproductions
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Quality aspects of recombinant proteins
Protein N-glycosylation in animal cells
Bibliography
The Ultimate Scientific and Technical Reference
