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4. Making a biochip
4.1 The importance of surface chemistry
As mentioned in the introduction, optical biochips require the involvement of several scientific disciplines (microelectronics, chemistry, biology, bioinformatics, optics, etc.). One of the key points in the implementation of biochip systems lies in mastering the production of active biochip surfaces. Indeed, the specifications for these surfaces are relatively restrictive: overall, they must be biochemically inert, except in the active zones forming the measurement pads, where each must be reactive to a specific target. .
In the case of DNA biochips, these pads are functionalized by single-stranded oligonucleotide sequences chosen to recognize complementary oligonucleotide...
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Making a biochip
Spatio-temporal self-calibration of a dynamic biochip
Bibliography
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Online catalog http://www.abes.fr/abes/index.html
Theses available online http://tel.archives-ouvertes.fr/
Patent pending
Patent FR n° 05 12 594, "Procédé d'auto-calibration de biopuces" – CNRS (13/12/2005). International extension PCT/EP2006/069683 – (13/12/2006).
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