1. Proteins and peptides

1.1 Composition and structure

Proteins are polypeptides, or unbranched polymers of amino acids. Amino acids carry two chemical functions: amine and carboxylic acid (figure 1 ). There are twenty naturally occurring amino acids, differentiated by the chemical groups R in their side chains, which give them their physico-chemical properties. The heavy atoms within the side chains are "numbered" in the order of the Greek alphabet, the α-carbon being the aliphatic carbon onto which the side chain grafts. Hydrogens are "numbered" according to the heavy atom to which they are bonded.

The twenty amino acids carry different types of side chains: uncharged aliphatic side chains,...

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Proteins and peptides

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page Protein structure by NMR

NMR of proteins in solution

Bibliography

References

(1) - CANTOR (C.R.), SCHIMMEL (P.R.) - Biophysical Chemistry Part II. - WH Freeman et Company (1980).
(2) - THORNTON (J.M.), ORENGO (C.A.), TODD (A.E.), PEARL (F.M.) - Protein folds, functions and evolution. - J. Mol....

Websites

Databases

Protein Data Bank (PDB) https://www.rcsb.org/

BioMaguResBank (BMRB) http://www.bmrb.wisc.edu

NMR, molecular modeling

NMR Information Server http://spincore.com/nmrinfo

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Manufacturers and suppliers

Fermenters are available to automatically control the culture of organisms for protein overexpression. These devices control pH, temperature and partial pressures of oxygen and carbon dioxide.

Fermenters

B Braun Biotech (Sartorius S.A) http://www.bbraunbiotech.com

Marked media and isotopes

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Software

The computers used for structural calculations are mainly UNIX-based workstations. This is due to the fact that the vast majority of programs are developed in a university environment under UNIX or LINUX, with a few exceptions (particularly molecule visualization programs) which run under Windows or MacOS.