Article | REF: AF3642 V1

Crystallization and polymorphism - Applications

Author: Michel BAUER

Publication date: July 10, 2004 | Lire en français

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    1. The essential consequences of polymorphism in the pharmaceutical field

    Previous articles and have already given a glimpse of the main consequences expected in the pharmaceutical sector.

    They mainly concern :

    • dissolution kinetics and, possibly, bioavailability;

    • the manufacturability of the active ingredient and the finished product;

    • the stability of the latter two.

    These areas have already been more or less developed, so we'll confine ourselves here to briefly touching on certain aspects.

    1.1 Polymorphism / dissolution kinetics and bioavailability

    Most drugs are still prescribed orally (tablets, capsules, suspensions,...

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