Article | REF: P3362 V1

Radionuclides - Application: molecular biology

Authors: François BOURREL, Philippe COURRIÈRE

Publication date: June 10, 2003

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4. Artifacts related to experimental conditions and tissue preparation

4.1 Distribution anomaly of radiolabelled compound

Low binding rates and limited biodistribution of the radiolabeled compound can be a source of false-negative images. This problem may result from poor barrier passage, poor blood flow, or impaired active or passive membrane transport (diffusion) due to membrane damage.

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4.2 Leakage and redistribution of radiolabelled compound and tissue constituents

Non-covalently bound radiolabeled compounds and tissue constituents not immobilized by fixatives can...

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Artifacts related to experimental conditions and tissue preparation