Article | REF: P226 V2

External validation of analytical methods

Author: Max FEINBERG

Publication date: March 10, 2024

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1. Validation and method life cycle

1.1 Analysis method life cycle

An analytical method is a procedure, i.e. a series of more or less complex, programmed operations, the aim of which is to determine an analyte. If we stick to strict metrological vocabulary, we should speak of measurand, rather than analyte. However, analysts have been able to gain acceptance for the latter term, which is better suited to their discipline.

A set of ancillary resources is used to implement this procedure. This is referred to as a measuring system. Analyte determination can be quantitative or qualitative.

As most analytes are difficult to relate to a standard in the International System (SI) of units, the initial question for an analyst is to ensure that what he or she is measuring corresponds...

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