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4. Functionalization of solid support
Before grafting the desired substrate onto a solid support, it is often advisable to introduce a spacer arm and/or a linker as shown in figure :
Indeed, if the active site is grafted directly onto the polymer backbone, its accessibility and therefore its reactivity may be reduced by the steric hindrance generated by the matrix.
4.1 Spacer arms
The introduction of a spacer arm moves the supported reaction site away from the polymer mesh. This is usually a more or less functionalized linear chain, which must be compatible...
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