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Article | REF: K1260 V1

Solid phase supported chemistry

Authors: Max Malacria, Jean-Philippe Goddard, Cyril Ollivier, Géraldine GOUHIER

Publication date: November 10, 2008

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4. Functionalization of solid support

Before grafting the desired substrate onto a solid support, it is often advisable to introduce a spacer arm and/or a linker as shown in figure :

Indeed, if the active site is grafted directly onto the polymer backbone, its accessibility and therefore its reactivity may be reduced by the steric hindrance generated by the matrix.

4.1 Spacer arms

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