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Article | REF: PHA1007 V2

Vector privileged chemical structures of therapeutic activities

Author: Pascal COUDERT

Publication date: March 10, 2024

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4. Tetracyclic derivatives

Two classes of drugs feature a sequence of 4 fused cyclohexanoperhydroanthracene rings. Structurally, tetracycline antibiotics have a single aromatic ring, a dimethylamine function and a substituted or unsubstituted amide function. In contrast, anthracyclines with anticancer properties share 2 aromatic rings and 1 aminosugar-type substituent (figure 7 ).

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Tetracyclic derivatives
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