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Article | REF: PHA2018 V1

Ophtalmic Preparations

Authors: Denis BROSSARD, Sylvie CRAUSTE-MANCIET

Publication date: December 10, 2014, Review date: November 30, 2023

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4. Eye drops

4.1 Solutions

Eye drops are the most widely used ophthalmic form, and a very large number of ophthalmic forms are marketed as solutions.

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4.1.1 Formulation

Formulation involves a number of excipients linked to the characteristics of the solution form and the active ingredient. For the latter, the essential points to study are its solubility, pH of solubility/stability in solution, osmotic activity and stability in solution. The main formulation steps involve dissolution/solubilization, adjustment...

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