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2. Therapeutic target identification and validation: with cells
Microfluidics can be used to isolate cells (essentially in droplets or chambers), creating controllable three-dimensional (3D) microenvironments for their culture, or to present them with a molecule or another cell. The applications are numerous, whether for the development of vaccines, antibodies, anti-infectives or anti-cancer drugs.
2.1 Identification of new targets
With the ultimate aim of developing a vaccine against human immunodeficiency virus-1 (HIV-1), Chaipan et al. have developed a microfluidic droplet system for isolating one virus per drop and studying its ability to bind neutralizing antibodies
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Therapeutic target identification and validation: with cells
Flow synthesis of active pharmaceutical ingredients
Bibliography
Standards and norms
- Microfluidic devices – Interoperability requirements concerning dimensions, connections and initial classification of devices - ISO 22916 - 2022
- Automated liquid handling systems – Part 1: Vocabulary and general requirements - ISO 23783-1 - 2022
- Microfluidics – Vocabulary - ISO 10991 - 2023
- Automated liquid handling systems – Uncertainty of measurement procedures - ISO/TR 6037 - 2024
Regulations
Commission Directive (EU) 2017/1572 of September 15, 2017 supplementing Directive 2001/83/EC of the European Parliament and of the Council as regards principles and guidelines of good manufacturing practice for medicinal products for human use (CELEX: 32017L1572)
Directory
European EMPIR project "Establishing metrology standards in microfluidic devices" (MFMET, 20NRM02): https://mfmet.eu
GDR Micro and Nanofluidics : https://www.gdrmicrofluidique.com
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