Article | REF: PHA2026 V1

Lyophilization of pharmaceutical and biopharmacetical products

Author: Alain HEDOUX

Publication date: September 10, 2013, Review date: February 12, 2021

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1. Physical phenomena underlying freeze-drying

The basic principles of freeze-drying, which is a procedure for eliminating water by sublimation of crystalline ice, are therefore based on changes in the state of water. This operation, the duration of which depends on the physical characteristics of the ice formed, follows physical mechanisms based on the matter and heat transfer phenomena involved in the sublimation phenomenon.

1.1 Changes in the physical state of water

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1.1.1 Pure water

Water is a simple material from a chemical point...

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Physical phenomena underlying freeze-drying