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3. Drug production tools
With the advent of increasingly sophisticated new technologies, the medicinal substances made available to patients are prepared with the aim of achieving greater specificity and lower toxicity. Nonetheless, classic production tools such as synthetic chemistry are still used today, and all the means used to obtain drugs are often complementary.
3.1 Traditional synthesis and hemisynthesis chemistry
The synthesis of small organic molecules (200 < PM < 600) for therapeutic purposes most often involves traditional organic chemistry reactions in solution, especially as the reagents used are multi-functional and therefore likely to lead to mixtures of end products.
Under these conditions, it becomes essential to optimize the yields...
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Bibliography
Bibliography
Molecular modeling software
Tripos : SYBYL X http://www.tripos.com
AMBER http://ambermd.org/
CHARMM http://www.charmm.org/
Websites
Sanofi-ENSTBB Biotech Chair – Biotechnologies and health: what are we talking about? http://www.enstbb.ipb.fr/fr/system/files/mmogouliko/resume_confs_biotechsante.pdf
CITELINE – The world's leading authority on pharmaceutical clinical trials
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