1. General presentation

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The search for new drugs has been greatly enriched by the contributions of combinatorial chemistry, high-throughput screening and molecular modeling. These tools, combined with advances in biology, have enabled the identification of original active principles, corresponding to lead compounds, whose optimization has led to the marketing of new drugs. However, the various drug targets have a protein, lipo- or glyco-protein structure, corresponding to enzymes, ion channels, membrane receptors or polynucleotides such as DNA. Such...