Article | REF: MED2000 V1

Sonodynamic therapy

Authors: Clément LINGER, Gabriel DUMY, Marc PORT

Publication date: March 10, 2021, Review date: March 10, 2021

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


Overview

Français

ABSTRACT

Sonodynamic therapy (SDT) is a therapeutic modality discovered in the 1990s but not yet approved for clinical applications. This technique uses targeted low-frequency ultrasound that activates sonosensitizers leading to apoptosis and cell death. SDT can treat tissues at great depths (4 to 10 cm). This article presents the physical principles of SDT, the mechanisms responsible for its biological effects, the different types of sonosensitizers and the medical applications envisaged.

Read this article from a comprehensive knowledge base, updated and supplemented with articles reviewed by scientific committees.

Read the article

AUTHORS

  • Clément LINGER: Master 2 - Chimie ParisTech, Université PSL, 2 rue Pierre et Marie Curie 75005 Paris, France

  • Gabriel DUMY: Post-doctoral fellow - PMMH Laboratory, ESPCI, Université PSL, 10 rue Vauquelin 75005 Paris, France

  • Marc PORT: CNAM Professor holding the "Chemical and Pharmaceutical Industries" Chair - Molecular Chemistry Team of the Genomics, Bioinformatics and Molecular Chemistry Laboratory (EA 7528), Conservatoire National des Arts et Métiers (CNAM), 2 rue Conté, 75003, HESAM University, Paris, France

 INTRODUCTION

Initially developed for diagnostic imaging, ultrasound is increasingly being considered for non-invasive therapeutic modalities. The use of high-intensity focused ultrasound (HIFU) is now a routine clinical practice for treating localized cancers (notably prostate and liver cancers) and uterine fibroids by hyperthermal effect. Focused ultrasound is also used to mechanically fractionate tissue or kidney and gallstones (histotripsy and lithotripsy), to destroy opaque crystalline lenses (cataracts) or to treat glaucoma by cyclo coagulation.

New clinical indications for HIFU are currently being developed, notably to treat patients with calcified aortic stenosis using a non-invasive method (Cardiawave technology currently undergoing clinical validation), or to deliver drugs targeting the central nervous system by transient opening of the blood-brain barrier.

However, an emerging field in preclinical – low-frequency sonotherapy – is based on the use of low-intensity ultrasound coupled with sonosensitizers to induce numerous cell-stress-inducing effects. These effects may be physical, such as mechanical shearing of the cell membrane or moderate hyperthermal effects. They can also be chemical, via cytotoxic effects induced by activated oxygen species produced by water pyrolysis, or sonoluminescence triggered by ultrasound and activated by sonosensitizers.

This article explains the physical principles of sonotherapy, as well as the parameters to be mastered to induce the ultrasonic effect relevant to activating cellular stress mechanisms. It also describes the different classes of organic or inorganic sonosensitizers used in the literature, and the medical applications envisaged. Although the clinical benefits of sonotherapy have yet to be fully demonstrated, we describe here the preclinical potential of sonotherapy and therapies combining it with other therapeutic modalities (chemotherapy, photodynamic therapy, radiotherapy, gene therapy and immunotherapy).

You do not have access to this resource.

Exclusive to subscribers. 97% yet to be discovered!

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


The Ultimate Scientific and Technical Reference

A Comprehensive Knowledge Base, with over 1,200 authors and 100 scientific advisors
+ More than 10,000 articles and 1,000 how-to sheets, over 800 new or updated articles every year
From design to prototyping, right through to industrialization, the reference for securing the development of your industrial projects

KEYWORDS

sonodynamic therapy   |   sonoluminescence   |   sonosensitizer   |   Reactive oxygen species   |   cavitation


This article is included in

Healthcare technologies

This offer includes:

Knowledge Base

Updated and enriched with articles validated by our scientific committees

Services

A set of exclusive tools to complement the resources

Practical Path

Operational and didactic, to guarantee the acquisition of transversal skills

Doc & Quiz

Interactive articles with quizzes, for constructive reading

Subscribe now!

Ongoing reading
Sonodynamic therapy