Article | REF: RE241 V1

Microfluidics and Tumor DNA - Contribution of digital PCR

Authors: Philippe NIZARD, Aurélie KROL, Pierre LAURENT-PUIG, Valérie TALY

Publication date: February 10, 2015

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2. Cancer and biomarkers

In recent years, cancer has become the leading cause of death, overtaking cardiovascular disease. It is the cause of a third of male deaths and a quarter of female deaths. In 2012 in France, 355,000 new cases of cancer were diagnosed, and 148,000 people died from it.

Cancer is a disease in which certain abnormal cells multiply anarchically, acquiring the ability to infiltrate and destroy healthy tissue to form a tumor. New sequencing technologies have revealed a complex network of genetic alterations present in cancer cells and absent from healthy cells. Depending on the alterations present, the prognosis and response to treatment may differ. As a result, early detection of these alterations now makes it possible to propose the most appropriate treatment, within the framework of so-called "targeted" therapies.

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