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3. Impact of environmental parameters on cell kinetics
Optimizing animal cell culture processes requires a better understanding of the interactions between cells and their environment within the reactor. Indeed, depending on the choice of operating parameters that determine this environment, the cell modifies its behavior (proliferation or death rates, morphology, metabolism, production and maturation capacities of the molecules produced). These operating parameters are manifold: reactor feed mode, culture system, medium composition, physico-chemical factors (figure 1 ).
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Impact of environmental parameters on cell kinetics
Bioreactors for mass culture of animal cells
Bibliography
Websites
LEEM study. Bioproduction in 2008: state of play and recommendations for French attractiveness. http://www.leem.org/dossier/101/etude-bioproduction-en-2008-etat-des-lieux-et-recommandations-pour-l-attractivite-1297.htm
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ESACT Congress, held every two years in Europe http://www.esact.org/meetings_esact.html
Congress of the engineering foundation: cell culture engineering, held every two years, mainly in the U.S.
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Organizations – Federations – Associations (non-exhaustive list)
ESACT Association: European Society of Animal Cell Technology http://www.esact.org/
Association ACTIP: Animal Cell Technology Industrial Platform http://www.actip.org/
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