Article | REF: N4950 V1

Calcium phosphate-based biomaterials

Authors: Christèle COMBES, Christian REY

Publication date: April 10, 2013

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1. From bone to bioactive ceramics

1.1 Bones and bone substitutes

From a materials science perspective, vertebrate bones can be defined as mineral-organic nanocomposites with an elaborate, controlled architecture. The organic matrix consists of type I collagen molecules, organized in a triple helix 1.2 nm in diameter and 300 nm in length, resulting from extracellular self-assembly. These molecules form fibrils with a particular organization, leaving gaps between successive molecules (figure 1 a )

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From bone to bioactive ceramics