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ABSTRACT
This article summarizes the uses and main characteristics of hybrid particles composed of a mineral core of bio-inspired apatite – possibly doped with (bio)active ions – decorated by an organic corona to confer biological properties or to control the size of the particles. Various biomedical applications are addressed for such (nano)systems, as in oncology, dermatology, hematology, gene therapy or medical diagnosis. These hybrid particles have two major advantages: their intrinsic biocompatibility and their possible multi-functionalization.
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Read the articleAUTHORS
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Mathilde GUÉRIN: Doctoral student - IBMM, Montpellier and CIRIMAT, Toulouse, France
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Gilles SUBRA: Doctor of Chemistry, Professor at the University of Montpellier, Faculty of Pharmacy - IBMM, Montpellier, France
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Christophe DROUET: Doctor of Materials Science, CNRS Research Director, CIRIMAT, Toulouse, France
INTRODUCTION
Calcium phosphates with an "apatite" structure are naturally present in the skeletal structure of vertebrates. It is now possible to prepare synthetic analogues inspired by these natural apatites, for biomedical applications. The development of bioactive bone substitutes such as matrices (porous or non-porous) or deposits on prostheses is the major field of application for these bio-inspired calcium phosphates. However, their "intrinsic" biocompatibility and high reactivity mean that many other therapeutic (dermatology, oncology, hematology, transfection, etc.) or diagnostic (medical imaging) applications can be envisaged. This involves modifying the composition of the particles' mineral core and/or adsorbing therapeutic agents to form a peripheral organic crown. Such mineral-organic particles are known as hybrids. Obtaining individualized particles, of submicron or even nanometric size, is particularly relevant for acting at cellular or tissue level, which may involve colloidal stabilization. This article reviews the main strategies concerning apatite-based mineral-organic hybrid particles for biomedical applications.
Key points
Field: biomedical, biomaterials, bio-inspiration, nanomedicine, calcium phosphates, colloids, particles
Degree of technology diffusion: Growth
Technologies involved: Colloidal synthesis, physicochemical characterization
Applications: (Nano)medicine, oncology, dermatology, hematology, gene therapy, medical imaging...
Main players in France :
Competitive clusters: EuroBiomed, Pôle Européen de la Céramique, Atlanpole Biothérapies, Lyonbiopôle, Alsace Biovalley, Medicen Paris Région, Nutrition-Santé-Longévité...
Competence centers: GdR CNRS/INSERM Réparer l'humain, GdR CNRS Biomimétisme et bio-inspiration, Commission MatSan "Matériaux pour la Santé" (SF2M/GFC/Cefracor/Titane), Biomat association, Institut Carnot Chimie Balard Cirimat...
Calcium phosphate manufacturers: 3DCeram, Biocetis, Biomatlante, Ceraver, Graftys, MedicalGroup, SBM, Teknimed, Urodelia...
Manufacturers in target biomedical applications: 3M, Brothier, Marion Technologies, MedicalGroup, Urgo, Urodelia...
Other global players: AAP Implants, Beiersdorf, CAM Bioceramics, DePuy Synthes, EincoBio, Etex, Finceramica, Himed, Hollister, Orchid Ortho, Smith & Nephew, Stryker, Subtilis Biomaterials, Tata Steel...
Contacts : [email protected] , [email protected]
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KEYWORDS
bio-inspiration | Apatites | Colloid | Hybrid particles
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Apatite-based inorganic-organic particles for biomedical applications
Apatite: a welcoming structure
Bibliography
Standards
- Biological evaluation of medical devices – Part 18: Chemical characterization of medical device materials as part of a risk management process. - ISO 10993-18 - 2020
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Groupe de recherche GdR CNRS " Biomim " Biomimétisme et bio-inspiration :
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