Article | REF: N4965 V1

Mineral adjuvants for vaccination in oncology

Author: Patrick FRAYSSINET

Publication date: April 10, 2014

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2. Mode of action of adjuvants

Five different adjuvant mechanisms of action have been identified:

  • immunomodulation, linked to the ability of adjuvants to modify cytokine synthesis, particularly by antigen-presenting cells;

  • presentation and the ability of the adjuvant to preserve the integrity of the antigen and present it to the appropriate immunocompetent cells;

  • induction of cytotoxic CD8+ lymphocytes;

  • targeting, linked to the adjuvant's ability to deliver antigen to immune effector cells via antigen-presenting cells;

  • progressive release of antigen from a solid matrix.

The use of adjuvants reduces the number of injections and the amount of antigen required for vaccination. Adjuvants can be administered...

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Mode of action of adjuvants