Article | REF: J8035 V1

Flash chemistry Ultra-fast microflow synthesis

Authors: Baptiste PICARD, Julien LEGROS

Publication date: September 10, 2019, Review date: October 23, 2020

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3. Flash chemistry in organic synthesis

3.1 Microfluidics and chemical selectivity

Selectivity is often used in organic synthesis to refer to the ability of a reaction to lead to the preferential formation of a single product out of several possible ones. However, this definition needs to be clarified to fully understand the phenomena at play in a microreactor. Selectivity is not related to a reaction per se, but should be considered as a system.

This system can be heterogeneous or homogeneous, and usually includes one or more reactants and catalysts, one or more solvents, a headspace (gaseous part of the reactor), a more or less homogeneous temperature, stirring (or not), and a given rate of progress at any given moment, and therefore potentially reaction...

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Flash chemistry in organic synthesis