Article | REF: J8035 V1

Flash chemistry Ultra-fast microflow synthesis

Authors: Baptiste PICARD, Julien LEGROS

Publication date: September 10, 2019, Review date: October 23, 2020

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4. Conclusion

Miniaturized continuous-flow reactors, known as microfluidics, have exceptional qualities, enabling them to carry out reactions that are impossible under conventional batch conditions. These qualities include excellent material (mixing) and heat (thermalization) transfer, extremely precise residence times in the microreactor (corresponding to the reaction time), and high reproducibility. When applied to organic synthesis, microfluidics makes it possible to act on extremely fast consecutive competitive reactions, for which the speed of the reaction mixture is no longer negligible and plays a role in the absence of selectivity. Flash reactions lasting just a few milliseconds in microreactors are particularly effective in organolithium chemistry, achieving results that are unattainable by any other synthesis technique. This continuous-flow selectivity can also be successfully applied to solve...

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