Article | REF: RE218 V1

Silk nanofibers-based biomaterials for biomedical applications

Authors: Guillaume VIDAL, Tony DINIS, Christophe EGLES

Publication date: April 10, 2013

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


Français

5. Biomedical applications of modified silk fibers

5.1 2D cell culture coatings

Numerous modified fibroin derivatives can be used as coatings for 2D cell culture substrates, to see to what extent surface chemistry or grafting of biological molecules can affect cell adhesion, growth and proliferation.

Conjugating fibroin to PLA increases hydrophilicity, with the contact angle dropping from 69° to 52°, leading to increased adhesion and osteoblast proliferation. PEG also increases hydrophilicity, with contact angles of 33°.

The incorporation of "Azo" moieties containing different groups that increase or decrease the hydrophilicity of fibroin can influence the growth and proliferation of human mesenchymal stem cells (hMSC). hMSCs proliferate best on hydrophilic fibroin derivatives with a...

You do not have access to this resource.

Exclusive to subscribers. 97% yet to be discovered!

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!


The Ultimate Scientific and Technical Reference

A Comprehensive Knowledge Base, with over 1,200 authors and 100 scientific advisors
+ More than 10,000 articles and 1,000 how-to sheets, over 800 new or updated articles every year
From design to prototyping, right through to industrialization, the reference for securing the development of your industrial projects

This article is included in

Nanosciences and nanotechnologies

This offer includes:

Knowledge Base

Updated and enriched with articles validated by our scientific committees

Services

A set of exclusive tools to complement the resources

Practical Path

Operational and didactic, to guarantee the acquisition of transversal skills

Doc & Quiz

Interactive articles with quizzes, for constructive reading

Subscribe now!

Ongoing reading
Biomedical applications of modified silk fibers