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3. Processes to generate liposomes
3.1 Introduction to liposomes
Liposomes are spherical vesicles composed of an aqueous core (intravesicular medium) and a membrane formed by one or several phospholipid bilayers. As phospholipids are amphiphilic, in the presence of water they spontaneously organize themselves so that the polar heads (phosphate groups) interact with water, and the hydrophobic tails (long hydrocarbon chains) are grouped together. This results in a structure that can encapsulate hydrophilic substances (in the aqueous core) together with hydrophobic substances (in the bilayer) or amphiphilic substances. As active ingredient vectors they are of great interest because:
they are non-toxic;
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Processes to generate liposomes
Impregnation processes
Bibliographic references
Patents
BOUTIN (O.). – Apparatus for forming particles of a target substance . US Patent 11/846,664 (2007).
CALDERONE (M.), RODIER (E.) et FORMULCOAT. – Procédé d’enrobage de poudres . Pub. FR 10.03.2006, WO2006/030112 (2006).
CASTOR (T.P.). – Methods and apparatus for making liposomes...
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