3. Comparison of techniques
Choosing the right method for a solvent-free reaction is not always a straightforward task, as not all methods will be suitable for every type of reaction. An example of a reaction comparing the efficiency of different methods for nitrone synthesis in the absence of solvent is described below.
Nitrones are important intermediates in organic synthesis. Among the various methods used to prepare them, the condensation reaction between an aldehyde and a hydroxylamine substituted on the nitrogen atom, in the presence of a base, is the most widely exploited. The condensation reaction can be carried out at different temperatures (cold, ambient or reflux) and reaction times are variable (from a few hours to two days), depending on the substrates. Anhydrous conditions and an excess of aldehyde are always required to achieve good yields (60-95%), chromatographic purification...
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
The Ultimate Scientific and Technical Reference
This article is included in
Green chemistry
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Comparison of techniques
Bibliography
References
Websites
http://www.epa.gov/greenchemistry/
http://www.rsc.org/chemsoc/gcn/
Standards – Regulations
French National Institute for Research and Safety (INRS)
Occupational Safety and Health Administration (OSHA)
European Agency for Safety and Health at Work
Directory
Organizations
US environmental Protection Agency
American Chemical Society Green Chemistry Institute ®
http://www.acs.org/greenchemistry
About photochemistry
...
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
The Ultimate Scientific and Technical Reference