Article | REF: BIO6810 V1

Therapeutic proteins production in insect cells

Author: Hassan CHAABIHI

Publication date: May 10, 2015

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4. Insect cell production and industrial developments

Recombinant proteins produced in insect cells are generated during a viral infection; their quantity and quality, as well as the reliability and reproducibility of the production process, are all dependent on the interaction between the virus and the host cell. This interaction depends not only on the genetic characteristics of the virus, but also on the cell's specific physiological parameters. To set up robust, reliable production processes that meet quality standards and regulatory constraints, it is essential to define as precisely as possible the parameters involved in virus-cell interaction.

4.1 Cell banks

The primary objective of a cell bank is to provide sufficient samples to initiate cultures throughout the...

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