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3. Toxicity and regulations
3.1 Indices
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Acute toxicity is defined by the lethal dose 50 (LD 50): this is the dose expressed in mg of active substance per kg of body weight (sometimes given in ppm, parts per million) that kills 50% of a batch of laboratory animals to which it is administered in a single dose.
The animal species to be tested and the route of administration (oral (ingestion), dermal (contact), inhalation or injection) must be specified. The LD50 of clopyralid, for example, is over 5,000 mg/kg for rats by ingestion. The results of studies on rats by ingestion are generally available. The transposition of this active substance to a preparation depends on its dosage and formulation.
Chronic...
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Toxicity and regulations
Formulations
Bibliography
Websites
http://www.eu-footprint.org/fr/ppdb.html
http://www.dive.afssa.fr/agritox/index.php
Regulations
Directive 91/414/EEC of July 15, 1991 concerning the placing of plant protection products on the market.
French Rural Code. Articles L. 253-1 to L. 253-8 – Placing plant protection products on the market. General provisions.
Directive 98/8/EC of February 16, 1998 concerning the placing of biocidal products on the market.
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Organizations
ECPA: Europe Crop Protection Association
UIPP: Union des industries de la protection des plantes (Union of plant protection industries)
UPJ: Union of companies for the protection of gardens and green spaces
EFSA: European Food Safety Agency
ANSES: Agence nationale de sécurité sanitaire de l'alimentation,...
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