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6. Epidemiology
6.1 Exposure windows and potential effects on offspring
The period of exposure is crucial. Developing organisms are more vulnerable (prenatal, perinatal, puberty, etc.). Hormonal activity is permanent during foetal and juvenile life, to ensure the organism's development. In adults, hormones act intermittently according to need, making them less vulnerable to PE.
The "window of exposure" corresponds to a stage in the development of primordial germ cells during which DNA methylation undergoes profound changes, being demethylated and then remethylated in a sex-specific manner.
Age of exposure plays a decisive role: teenage girls exposed to DDT before the age of 14 are 5 times more likely to develop breast cancer than...
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Epidemiology
Suspected endocrine disruptors
Bibliography
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INERIS
INSERM
Regulations
France
Law no. 2012-1442 of December 24, 2012 aimed at suspending the manufacture, import, export and marketing of any food packaging containing bisphenol A.
European Union
Regulation (EU) No. 528/2012 of the European Parliament and of the Council of May 22, 2012 concerning the making available on the market and use of biocidal products.
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