Article | REF: PHA1005 V2

Current and future sources of drugs

Author: Pascal COUDERT

Publication date: August 10, 2020, Review date: April 28, 2021

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3. Drug production tools

With the advent of increasingly sophisticated new technologies, the medicinal substances made available to patients are prepared with the aim of achieving greater specificity and lower toxicity. Nonetheless, classic production tools such as synthetic chemistry are still used today, and all the means used to obtain drugs are often complementary.

3.1 Traditional synthesis and hemisynthesis chemistry

The synthesis of small organic molecules (200 < PM < 600) for therapeutic purposes most often involves traditional organic chemistry reactions in solution, especially as the reagents used are multi-functional and therefore likely to lead to mixtures of end products.

Under these conditions, it becomes essential to optimize the yields...

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Drug production tools