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2. Quality aspects of recombinant proteins
2.1 Post-translational changes
Posttranslational modifications (PTMs) include protein aggregation, methionine oxidation, deamination of asparagine and to a lesser extent glutamine, lipid addition, proteolysis, γ-carboxylation, glycosylation and protein sulfation .
Such modifications not only represent a challenge for the production process, but above all can have undesirable consequences for the patient. Incorrect TPMs can not only reduce the protein's efficacy, but...
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Quality aspects of recombinant proteins
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