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4. Lipid nanovectors as nanomedicines
4.1 Interactions with biological media: nanotoxicity
For several years now, the chemical industry and its technological advances have made available to formulators a multitude of ingredients of varying degrees of purity, and in significant quantities. In just a few years, the range of lipids derived from the refining of oils of various origins has tripled. However, they must be chosen rationally, based on their physicochemical properties and safety (non-toxicity), in order to be used as excipients in the composition of nanomedicines. The list entitled Inactive Ingredients Guide (IIG) drawn up by the Food and Drug Administration (FDA) –, indicating materials already tested, their quantity and the route of administration for which they are approved –, is a valuable aid in this choice....
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Lipid nanovectors as nanomedicines
Bibliography
Digital media
CNRS sagascience: vectorization file http://www.cnrs.fr/cw/dossiers/dosnano/decouv/vecto/vecto.htm
Websites
NANOSAFE: use and production of nanomaterials http://www.nanosafe.org
Events
World Congress on Emulsion. International trade fair on fundamental and applied aspects of emulsions, held every 4 years at the Palais des Congrès in Lyon, France. http://www.cme-emulsion.com
PharmSciFair. International trade fair on fundamental and applied aspects of pharmaceutical sciences, held every 2 years in a European city....
Standards and norms
European Technological Platform for Nanomedecine, Nanotechnology for Health: Vision paper and basis for a strategic research agenda for nanomedecine, ETPN, 2005, European Commission Publication Office, Brussels
Cancer Nanotechnology Plan: a strategic initiative to transform clinical oncology and basic research through the direct application of nanotechnology, NIOH, National Cancer Institute,...
Regulations
Agence Nationale de Sécurité du Médicament et des Produits de Santé ANSM: an agency whose mission is to guarantee the safety of healthcare products throughout their life cycle. It issues marketing authorizations for drugs (AMM) and clinical trial authorizations. http://ansm.sante.fr
US Food and Drug Administration: federal agency regulating...
Patents
Recent advances and patents on Solid Lipid nanoparticles. in Recent patent on drug delivery and formulation, 2008, 2, 120-135
Process for producing nano-emulsions. WO/2008/104717
Encapsulation of lipophilic or amphiphilic therapeutic agents in nanoemulsions. WO/2010/018223
Lipid nanocapsules, preparation method and use as medicine. WO/2001/064328...
Directory
Manufacturers – Suppliers – Distributors (non-exhaustive list)
GEA Niro Soavi, suppliers of high-pressure homogenizers http://www.nirosoavi.com
Microfluidics Corporation, suppliers of microfluidic homogenizers http://www.microfluidicscorp.com
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