Article | REF: J6008 V1

Biotechnology-based antibiotic production

Authors: Stéphane DELAUNAY, Emmanuel RONDAGS, Pierre GERMAIN

Publication date: September 10, 2003, Review date: September 1, 2016

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4. Industrial implementation

The performance of a culture for the industrial production of antibiotics depends on its technological capacity to achieve the following three major objectives:

  • achieve efficient growth resulting in a large quantity of biomass in a physiological state compatible with production. In some cases, very good growth can result in the production of biomass unsuitable for antibiotic synthesis;

  • maintain biomass in optimal production conditions for as long as possible;

  • ensure that the growth and production phases, as well as the extraction and purification stages, are as cost-effective as possible.

4.1 Inoculum preparation

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