3. Protein N-glycosylation in animal cells
3.1 Glycoprotein biosynthesis in animal cells
Glycoproteins are assembled first in the endoplasmic reticulum (ER) and then in the Golgi apparatus. Glycoproteins are generally secreted, membrane or resident proteins of these two compartments, which implies that they possess a signal sequence governing their translocation to the ER.
The synthesis of an N-glycosylprotein requires the prior elaboration of a glycan consisting of fourteen monosaccharides on a polyisoprenic lipid embedded in the ER membrane, dolichol phosphate (Dol-P). Assembly of the oligosaccharide takes place sequentially via a very specific metabolic cycle known as the "dolichol cycle"
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
The Ultimate Scientific and Technical Reference
This article is included in
Healthcare technologies
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Protein N-glycosylation in animal cells
Bibliography
Exclusive to subscribers. 97% yet to be discovered!
You do not have access to this resource.
Click here to request your free trial access!
Already subscribed? Log in!
The Ultimate Scientific and Technical Reference