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2. Mode of action of adjuvants
Five different adjuvant mechanisms of action have been identified:
immunomodulation, linked to the ability of adjuvants to modify cytokine synthesis, particularly by antigen-presenting cells;
presentation and the ability of the adjuvant to preserve the integrity of the antigen and present it to the appropriate immunocompetent cells;
induction of cytotoxic CD8+ lymphocytes;
targeting, linked to the adjuvant's ability to deliver antigen to immune effector cells via antigen-presenting cells;
progressive release of antigen from a solid matrix.
The use of adjuvants reduces the number of injections and the amount of antigen required for vaccination. Adjuvants can be administered...
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Mode of action of adjuvants
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