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2. In vitro experimental procedures specific to biomaterials
The experimental methods recommended for assessing the biocompatibility of biomaterials are rather limited. They are based on four successive, selective stages, which gradually reduce the number of materials to be tested . The selection sequence consists of :
1) in vitro corrosion tests in an organic medium (as well as wear and friction tests);
2) in vitro corrosion tests (wear and friction tests can also be carried out at this stage) in a mixed inorganic-organic medium;
3) examinations after contact with cell cultures;
4) in vivo tests based on animal implantation....
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In vitro experimental procedures specific to biomaterials
Behavior of different biomaterial families in natural and synthetic physiological environments
Bibliography
Websites
On biocompatibility and the different alloys used http://membres.lycos.fr/atollimplant/tolerance.htm
Dental implants and osseointegration http://www.implants-dchappuis.ch/implants.htm
Norms and Standards
- Dental art – Metallic materials for fixed and removable restorations and appliances - EN ISO 22674 - 2006
- Surgical implants – High-density alumina-based ceramic products - ISO 6474 - 1994
Statistical and economic data
In industrialized countries, the lifespan of the population is increasing (figure 1 ), which may partly explain the growing development of biomaterials....
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