Article | REF: J5720 V1

Nitration of aromatic compounds

Author: Pascal METIVIER

Publication date: September 10, 1998

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2. Nitration chemistry

2.1 Aromatic electrophilic nitration: general mechanism

This reaction was the subject of a very large number of studies in the 1960s-1980s . The net balance of the reaction is extremely simple and attractive from an economic and environmental point of view, since there is stoichiometric consumption of one equivalent of nitric acid (an inexpensive reagent) with co-production of one equivalent of water. The reaction is generally carried out in a strong acid medium, with the nitronium ion

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Nitration chemistry