Français
5. Methods for characterizing endocrine disruptors
All available information on a chemical substance is used to characterize its endocrine disrupting potential, from the study of chemical formulations to tests on whole organisms.
5.1 In silico" or crystallographic methods
They involve the study of structure-activity relationships (QSAR) and the modeling of ligand-receptor binding.
The QSAR (Quantitative Structure Activity Relationship) method is the establishment of a quantitative relationship between a chemical structure and an activity in the form of chemical reactivity or biological activity. For example, the presence of benzene rings with an HO function in the chemical structure, as in the case of estradiol (figure 7...
The Ultimate Scientific and Technical Reference
This article is included in
Safety and risk management
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Methods for characterizing endocrine disruptors
Epidemiology
Bibliography
Websites
INERIS
INSERM
Regulations
France
Law no. 2012-1442 of December 24, 2012 aimed at suspending the manufacture, import, export and marketing of any food packaging containing bisphenol A.
European Union
Regulation (EU) No. 528/2012 of the European Parliament and of the Council of May 22, 2012 concerning the making available on the market and use of biocidal products.
...
The Ultimate Scientific and Technical Reference
